Dustin Byfuglien had a chance to tie but sent his slap shot just wide. The two teams engaged in a nine-round shootout Oct. 10, with the Blackhawks winning.
Ryan O'Reilly scored twice for Colorado in regulation, while David Jones added a short-handed goal.
The Avalanche moved to 6-0 at Pepsi Center this season, matching the franchise record for consecutive home wins to start a season.
Byfuglien, Duncan Keith and Andrew Ladd scored for the Blackhawks, who lost for the second consecutive night.
Craig Anderson returned to the net after receiving a rare night off. The Avalanche goalie stopped 29 shots.